Cellular consequences of transthyretin deposition.

Abstract excerpt

Mutant forms of transthyretin (TTR) deposit in tissues of patients presenting with familial amyloidotic polyneuropathy (FAP). The cellular consequences of tissue TTR deposition have only been addressed recently and are summarized here. Inflammatory and oxidative stress pathways are triggered by fibrillar and non-fibrillar TTR deposits, a fact to take into account in future forms of FAP treatment.

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