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Article

Discovery of alpha 1-antitrypsin deficiency.

Lung - 1 Jan 1990

Eriksson S

Abstract excerpt

The author reviews the early history of alpha 1-antitrypsin (AAT) deficiency; the biochemical characterization of this inborn error of metabolism, its pattern of inheritance, frequency and predisposition to early, panacinar emphysema. The importance of the destructive element in emphysema and the gradual focusing on neutrophil elastase as a key enzyme in the pathogenesis of emphysema in alpha 1-antitrypsin...

Topics

Humans
Liver Cirrhosis
Phenotype
Pulmonary Emphysema
Risk Factors
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2117160
DOI: 10.1007/BF02718174

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2117160-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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