Article
A review of alpha-1 antitrypsin deficiency.
Seminars in respiratory and critical care medicine - 1 Apr 2005
Ranes Justin, Stoller James K
Abstract excerpt
Alpha-1 antitrypsin (AAT) is a protein that prevents enzymes such as elastin from degrading normal host tissue. Individuals who are deficient in AAT (those with levels < 11 micromol/L) are at risk for developing such clinical manifestations as emphysema, cirrhosis, panniculitis, and anticytoplasmic neutrophilic antibody (C-ANCA)-positive vasculitis (Wegener's granulomatosis). Estimates suggest that 75 to 85% of...
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