Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus

19 Feb 2008

Abstract excerpt

The 1918 influenza pandemic was exceptionally severe, resulting in the death of up to 50 million people worldwide. Here, we show which virus genes contributed to the replication and virulence of the 1918 influenza virus. Recombinant viruses, in which genes of the 1918 virus were replaced with genes from a contemporary human H1N1 influenza virus, A/Texas/36/91 (Tx/91), were generated. The exchange of most 1918...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza Virus Research Studies
Share to interferon and immune responses
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18287069
DOI: 10.1073/pnas.0711815105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virusPMID 18287069Read ↗

Analysis by Single-Gene Reassortment Demonstrates that the 1918 Influenza Virus Is Functionally Compatible with a Low-Pathogenicity Avian Influenza Virus in MiceSemantic proximity Read ↗

Resurrected Pandemic Influenza VirusesSemantic proximity Read ↗

The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism PathwaysSemantic proximity Read ↗

Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferretsSemantic proximity Read ↗

Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virusSemantic proximity Read ↗

Characterization of the Reconstructed 1918 Spanish Influenza Pandemic VirusSemantic proximity Read ↗

Altered virulence of Highly Pathogenic Avian Influenza (HPAI) H5N8 reassortant viruses in mammalian modelsSemantic proximity Read ↗

Virulence and Genetic Compatibility of Polymerase Reassortant Viruses Derived from the Pandemic (H1N1) 2009 Influenza Virus and Circulating Influenza A VirusesSemantic proximity Read ↗

Effect of pandemic influenza A virus PB1 genes of avian origin on viral RNA polymerase activity and pathogenicitySemantic proximity Read ↗

1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in MiceSemantic proximity Read ↗

NP, PB1, and PB2 Viral Genes Contribute to Altered Replication of H5N1 Avian Influenza Viruses in ChickensSemantic proximity Read ↗

Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.