Article
Impact of CYP2C19 polymorphism on residual platelet reactivity in patients with coronary heart disease during antiplatelet therapy.
Journal of cardiology - 1 Mar 2011
Yamamoto Koichiro, Hokimoto Seiji, Chitose Tadasuke, Morita Kazunori, Ono Takamichi, Kaikita Koichi, Tsujita Kenichi, Abe Tomohide, Deguchi Mariko, Miyagawa Haruna, Saruwatari Junji, Sumida Hitoshi, Sugiyama Seigo, Nakagawa Kazuko, Ogawa Hisao
Abstract excerpt
BACKGROUND AND PURPOSE: CYP2C19*2 loss-of-function allele in Caucasians may be associated with wide interindividual variability in platelet response to clopidogrel, and the incidence of gene mutation varies with racial differences, especially between Asians and Caucasians. The aim was to examine the impact of CYP2C19 genotype on the residual platelet reactivity in Japanese patients with coronary heart disease...
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