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Article

Impact of CYP2C19 polymorphism and proton pump inhibitors on platelet reactivity to clopidogrel and clinical outcomes following stent implantation.

Thrombosis research - 1 Apr 2014

Hokimoto Seiji, Mizobe Michio, Akasaka Tomonori, Arima Yuichiro, Kaikita Koichi, Nakagawa Kazuko, Ogawa Hisao

Abstract excerpt

BACKGROUND: The response to clopidogrel, and some kind of the drug interaction are multifactorial. METHODS AND RESULTS: We enrolled 174 consecutive patients and determined CYP2C19 genotypes, measured platelet aggregation, and assessed the relationship between CYP2C19 genotype and platelet reactivity 24hours after clopidogrel administration, and the risk of cardiovascular events over 18months follow-up. A sub...

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Source

Identifiers

PMID: 24440142
DOI: 10.1016/j.thromres.2014.01.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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