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Alzheimer’s Disease Biomarkers and Epigenetic Intermediates Following Exposure to Pb In Vitro

2 May 2012

Abstract excerpt

Late onset Alzheimer's disease (LOAD) is typical of the majority of Alzheimer's disease (AD) cases (~90%), and has no clear genetic association. Previous studies from our lab suggest that an epigenetic component could be involved. Developmental exposure of primates and rodents to lead (Pb) predetermined the expression of AD-related genes, such as the amyloid-β precursor protein (AβPP), later in life. In addition...

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PMID: 22272629
DOI: 10.2174/156720512800617964

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