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Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice

21 May 2002

Abstract excerpt

Epidemiological studies have implicated aluminum (Al) exposure in the pathogenesis of Alzheimer's disease (AD); however, other studies have failed to confirm these results. Oxidative stress is a feature of AD, and Al can exacerbate oxidative events. This biological property has been suggested as a possible mechanism by which this metal could influence the onset and/or evolution of the disease. To test this...

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PMID: 12039845
DOI: 10.1096/fj.02-0012fje

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