Article
Extreme differences in charge changes during protein evolution.
Journal of molecular evolution - 1 Jul 1990
Leunissen J A, van den Hooven H W, de Jong W W
Abstract excerpt
The maintenance of a proper distribution of charged amino acid residues might be expected to be an important factor in protein evolution. We therefore compared the inferred changes in charge during the evolution of 43 protein families with the changes expected on the basis of random base substitutions. It was found that certain proteins, like the eye lens crystallins and most histones, display an extreme...
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