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Article

The Evolution of Combinatorial Gene Regulation in Fungi

22 Feb 2008

Abstract excerpt

It is widely suspected that gene regulatory networks are highly plastic. The rapid turnover of transcription factor binding sites has been predicted on theoretical grounds and has been experimentally demonstrated in closely related species. We combined experimental approaches with comparative genomics to focus on the role of combinatorial control in the evolution of a large transcriptional circuit in the fungal...

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PMID: 18303948
DOI: 10.1371/journal.pbio.0060038

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