Article
Beyond the consensus: dissecting within-host viral population diversity of foot-and-mouth disease virus by using next-generation genome sequencing.
Journal of virology - 1 Mar 2011
Wright Caroline F, Morelli Marco J, Thébaud Gaël, Knowles Nick J, Herzyk Pawel, Paton David J, Haydon Daniel T, King Donald P
Abstract excerpt
The diverse sequences of viral populations within individual hosts are the starting material for selection and subsequent evolution of RNA viruses such as foot-and-mouth disease virus (FMDV). Using next-generation sequencing (NGS) performed on a Genome Analyzer platform (Illumina), this study compared the viral populations within two bovine epithelial samples (foot lesions) from a single animal with the inoculum...
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