Article
Phenotypic changes of lymphocytes in patients with systemic lupus erythematosus who are in longterm remission after B cell depletion therapy with rituximab.
The Journal of rheumatology - 1 Apr 2011
Iwata Shigeru, Saito Kazuyoshi, Tokunaga Mikiko, Yamaoka Kunihiro, Nawata Masao, Yukawa Sonosuke, Hanami Kentaro, Fukuyo Shunsuke, Miyagawa Ippei, Kubo Satoshi, Tanaka Yoshiya
Abstract excerpt
OBJECTIVE: Rituximab has recently emerged as a novel treatment strategy for systemic lupus erythematosus (SLE). We investigated longitudinally the differentiation and phenotypic changes of peripheral B cells and T cells in patients with SLE after rituximab treatment. METHODS: Phenotypic changes on B cells and T cells in 10 patients with SLE treated with rituximab were analyzed before, 28 days after, and 2 years...
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