Article
Aberrant expression of immunoglobulin light chain isotype in B lymphocytes from patients with monoclonal gammopathies: isotypic discordance and clonal B-cell excess.
British journal of haematology - 1 May 1990
Oritani K, Katagiri S, Tominaga N, Iida M, Amano T, Karasuno T, Matsumura I, Mitsui H, Kanayama Y, Yonezawa T
Abstract excerpt
A study was made of 29 patients with monoclonal gammopathies to detect aberrations in immunoglobulin (Ig) light chain isotype expression in lymphocytes at various levels of B-cell differentiation, namely, circulating surface Ig positive (SIg+) cells, Ig-secreting cells (plaque forming cells, PFC)...
Topics
- Antibody-Producing Cells
- Antigens, Surface
- B-Lymphocytes
- Bone Marrow
- Cell Division
- Hemolytic Plaque Technique
- Humans
- Immunoglobulin Isotypes
- Immunoglobulin Light Chains
- Multiple Myeloma
- Paraproteinemias
- Phenotype