Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome.

doi:10.1097/NEN.0b013e318202bfa1

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Article

Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome.

Journal of neuropathology and experimental neurology - 1 Jan 2011

Wegiel Jerzy, Kaczmarski Wojciech, Barua Madhabi, Kuchna Izabela, Nowicki Krzysztof, Wang Kuo-Chiang, Wegiel Jarek, Yang Shuang Ma, Frackowiak Janusz, Mazur-Kolecka Bozena, Silverman Wayne P, Reisberg Barry, Monteiro Isabel, de Leon Mony, Wisniewski Thomas, Dalton Arthur, Lai Florence, Hwang Yu-Wen, Adayev Tatyana, Liu Fei, Iqbal Khalid, Iqbal Inge-Grundke, Gong Cheng-Xin

Abstract excerpt

Triplication of chromosome 21 in Down syndrome (DS) results in overexpression of the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A gene (DYRK1A). DYRK1A phosphorylates cytoplasmic tau protein and appears in intraneuronal neurofibrillary tangles (NFTs). We have previously shown significantly more DYRK1A-positive NFTs in DS brains than in sporadic Alzheimer disease (AD) brains....

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Identifiers

PMID: 21157379
DOI: 10.1097/NEN.0b013e318202bfa1
PMCID: PMC3083064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome.PMID 21157379Read ↗

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