Article
Mutations in the Na-Cl cotransporter reduce blood pressure in humans.
Hypertension (Dallas, Tex. : 1979) - 1 Jun 2001
Cruz D N, Simon D B, Nelson-Williams C, Farhi A, Finberg K, Burleson L, Gill J R, Lifton R P
Abstract excerpt
The relationship between salt homeostasis and blood pressure has remained difficult to establish from epidemiological studies of the general population. Recently, mendelian forms of hypertension have demonstrated that mutations that increase renal salt balance lead to higher blood pressure, suggesting that mutations that decrease the net salt balance might have the converse effect. Gitelman's syndrome, caused by...
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