CXCL10 reduces melanoma proliferation and invasiveness in vitro and in vivo

Abstract excerpt

BACKGROUND: Melanoma is often infiltrated by inflammatory and immune cells that might either maintain chronic inflammation, therefore promoting tumour growth, or mount an antitumour response to control tumour outcome. In this setting, Th1-oriented lymphocyte infiltration is associated with a better outcome in melanoma. Although the interferon-induced protein CXCL10 is expressed by Th1 immune cells, its receptor...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer Immunotherapy and Biomarkers
• Share to Chemokine receptors and signaling
• Share to Cutaneous Melanoma Detection and Management