Article
Apolipoprotein AIMilano. Disulfide-linked dimers increase high density lipoprotein stability and hinder particle interconversion in carrier plasma.
The Journal of biological chemistry - 25 Jul 1990
Franceschini G, Calabresi L, Tosi C, Gianfranceschi G, Sirtori C R, Nichols A V
Abstract excerpt
The in vitro metabolism of high density lipoproteins (HDL) in carriers of the apolipoprotein AIMilano (apoAIM) mutant was investigated during incubation of whole plasma and isolated lipoprotein fractions. A reduced cholesterol esterification (16.5 versus 25.0% for controls) and a decreased exchan...
Topics
- Apolipoprotein A-I
- Apolipoproteins A
- Carrier Proteins
- Cholesterol
- Cholesterol Esters
- Disulfides
- Heterozygote
- Humans
- Lipoproteins, HDL
- Mutation
- Phosphatidylcholine-Sterol O-Acyltransferase
- Triglycerides