Article
Apolipoprotein A-IFIN (Leu159-->Arg) mutation affects lecithin cholesterol acyltransferase activation and subclass distribution of HDL but not cholesterol efflux from fibroblasts.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1997
Miettinen H E, Jauhiainen M, Gylling H, Ehnholm S, Palomäki A, Miettinen T A, Kontula K
Abstract excerpt
We showed earlier that the apolipoprotein A-I Leu159-->Arg mutation (apoA-IFin) results in dominantly inherited hypoalphalipoproteinemia. In the present study we investigated the effect of the apoA-IFin mutation on lipoprotein profile, apoA-I kinetics, lecithin:cholesterol acyltransferase (LCAT) activation, and cholesterol efflux in vitro. Carriers (n = 9) of the apoA-IFin mutation exhibited several lipoprotein...
Topics
- Adolescent
- Adult
- Aged
- Apolipoprotein A-I
- Carrier Proteins
- Cholesterol
- Cholesterol Ester Transfer Proteins
- Enzyme Activation
- Female
- Fibroblasts