Article
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
Nature genetics - 1 Jan 2011
Chen Zi-Jiang, Zhao Han, He Lin, Shi Yuhua, Qin Yingying, Shi Yongyong, Li Zhiqiang, You Li, Zhao Junli, Liu Jiayin, Liang Xiaoyan, Zhao Xiaoming, Zhao Junzhao, Sun Yingpu, Zhang Bo, Jiang Hong, Zhao Dongni, Bian Yuehong, Gao Xuan, Geng Ling, Li Yiran, Zhu Dongyi, Sun Xiuqin, Xu Jin-E, Hao Cuifang, Ren Chun-E, Zhang Yajie, Chen Shiling, Zhang Wei, Yang Aijun, Yan Junhao, Li Yuan, Ma Jinlong, Zhao Yueran
Abstract excerpt
Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han...
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