Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

doi:10.1038/ncomms8502

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Article

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

Nature communications - 18 Aug 2015

Hayes M Geoffrey, Urbanek Margrit, Ehrmann David A, Armstrong Loren L, Lee Ji Young, Sisk Ryan, Karaderi Tugce, Barber Thomas M, McCarthy Mark I, Franks Stephen, Lindgren Cecilia M, Welt Corrine K, Diamanti-Kandarakis Evanthia, Panidis Dimitrios, Goodarzi Mark O, Azziz Ricardo, Zhang Yi, James Roland G, Olivier Michael, Kissebah Ahmed H, Stener-Victorin Elisabet, Legro Richard S, Dunaif Andrea

Abstract excerpt

Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating hormone secretion, insulin resistance and developmental exposure to androgens are hypothesized to play a causal role in PCOS. Here we map common genetic...

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PMID: 26284813
DOI: 10.1038/ncomms8502
PMCID: PMC4557132

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