Article
Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster.
Neuron - 1 Jul 1990
Jiménez F, Campos-Ortega J A
Abstract excerpt
Loss of function mutations in genes of the achaete-scute complex (ASC) or in the gene vnd of D. melanogaster result in neural hypoplasia. Two types of defects contribute to the development of the neural hypoplasic phenotype: a lower than normal proportion of neuroblasts delaminate from the neuroectoderm, and there is abundant cell death in the neural primordium during later stages. In addition, we found that...
Topics
- Animals
- Cell Survival
- Drosophila melanogaster
- Embryo, Nonmammalian
- Genes
- Mutation
- Nervous System
- Nervous System Malformations
- Neurons
- Phenotype