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Generation of Viable Male and Female Mice from Two Fathers1

9 Dec 2010

Abstract excerpt

In sexual species, fertilization of oocytes produces individuals with alleles derived from both parents. Here we use pluripotent stem cells derived from somatic cells to combine the haploid genomes from two males to produce viable sons and daughters. Male (XY) mouse induced pluripotent stem cells (Father #1) were used to isolate subclones that had spontaneously lost the Y chromosome to become genetically female...

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PMID: 21148107
DOI: 10.1095/biolreprod.110.088831

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