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Article

Formation of antiviral cytoplasmic granules during orthopoxvirus infection.

Journal of virology - 1 Feb 2011

Simpson-Holley M, Kedersha N, Dower K, Rubins K H, Anderson P, Hensley L E, Connor J H

Abstract excerpt

Vaccinia virus (VV) mutants lacking the double-stranded RNA (dsRNA)-binding E3L protein (ΔE3L mutant VV) show restricted replication in most cell types, as dsRNA produced by VV activates protein kinase R (PKR), leading to eIF2α phosphorylation and impaired translation initiation. Here we show that cells infected with ΔE3L mutant VV assemble cytoplasmic granular structures which surround the VV replication...

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Source

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Identifiers

PMID: 21147913
DOI: 10.1128/JVI.02247-10
PMCID: PMC3028896

Genes

USP10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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