Article
Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants.
PLoS pathogens - 1 Jul 2026
Steinbock Robert T, Scudero Orlando B, Dybas Joseph M, Abbott Amber R N, Kulej Katarzyna, Lauman Richard, Chan Holly, Agostino Eva L, Kumar Namrata, Stone Cameron, Briggs Skyler, Parenti Nicholas A, Li Yize, Burke James M, Weiss Susan R, Price Alexander M, Weitzman Matthew D
Abstract excerpt
Recognition of double-stranded RNA (dsRNA) triggers antiviral defense mediated by PKR and OAS3/RNase L pathways through translational arrest and RNA decay. This is accompanied by assembly of distinct cytoplasmic ribonucleoprotein (RNP) condensates termed stress granules (SGs) and RNase L-dependent bodies (RLBs). Here we show that adenovirus mutants engage distinct RNA-sensing pathways and promote differential...
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