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A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis

13 Nov 2010

Abstract excerpt

The p53 inactivation caused by aberrant expression of its major regulators (e.g., MDM2 and MDMX) contributes to the genesis of a large number of human cancers. Recent studies have shown that restoration of p53 activity by counteracting p53 repressors is a promising anticancer strategy. Although agents (e.g., nutlin-3a) that disrupt MDM2-p53 interaction can inhibit tumor growth, they are less effective in cancer...

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PMID: 21075910
DOI: 10.1158/1535-7163.mct-10-0581

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