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Article

IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype.

Cell death & disease - 1 Oct 2015

Kessler S M, Laggai S, Barghash A, Schultheiss C S, Lederer E, Artl M, Helms V, Haybaeck J, Kiemer A K

Abstract excerpt

Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related deaths and commonly develops in inflammatory environments. The IGF2 mRNA-binding protein IMP2-2/IGF2BP2-2/p62 was originally identified as an autoantigen in HCC. Aim of this study was to investigate a potential pathophysiological role of p62 in hepatocarcinogenesis. Human HCC tissue showed overexpression of IMP2, which strongly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26426686
DOI: 10.1038/cddis.2015.241
PMCID: PMC4632283

Genes

DLK1
AFP
IGF2
RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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