Article
Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species (Saguinus oedipus).
Immunogenetics - 1 Jan 1991
Watkins D I, Garber T L, Chen Z W, Toukatly G, Hughes A L, Letvin N L
Abstract excerpt
Although major histocompatibility complex (MHC) class I molecules are, as a rule, highly polymorphic in mammalian species, those of the New World primate Saguinus oedipus (cotton-top tamarin) exhibit limited polymorphism. We have cloned and sequenced twelve MHC class I cDNAs from this species. Since cloned cotton-top tamarin cell lines express three to six MHC class I molecules, this species must have at least...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- Genes, MHC Class I
- Genetic Variation
- Molecular Sequence Data
- Pseudogenes
- Restriction Mapping
- Saguinus
- Selection, Genetic