Article
Molecular analysis of constitutively expressed erm(C) genes selected in vitro by incubation in the presence of the noninducers quinupristin, telithromycin, or ABT-773.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2002
Schmitz Franz-Josef, Petridou Jasmina, Astfalk Nadine, Köhrer Karl, Scheuring Sybille, Schwarz Stefan
Abstract excerpt
A Staphylococcus aureus strain that harbored a plasmid-borne inducibly expressed erm(C) gene was cultivated in the presence of the noninducers quinupristin, telithromycin, and ABT-773. After overnight incubation, 78 mutants that displayed combined resistance to macrolides, lincosamides, streptogramin B antibiotics, and ketolides were analyzed for the genetic basis of this altered resistance phenotype. Because...
Topics
- Anti-Bacterial Agents
- Drug Resistance, Microbial
- Erythromycin
- Genes, Bacterial
- In Vitro Techniques
- Ketolides
- Macrolides
- Microbial Sensitivity Tests
- Mutation
- Protein Biosynthesis
- Selection, Genetic
- Staphylococcus aureus
- Virginiamycin