Article
Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2011
Wei Jian-Jun, Wu Xinyu, Peng Yi, Shi Guizhi, Basturk Olca, Olca Basturk, Yang Ximing, Daniels Garrett, Osman Iman, Ouyang Jiangyong, Hernando Eva, Pellicer Angel, Rhim Johng S, Melamed Jonathan, Lee Peng
Abstract excerpt
PURPOSE: High-motility group AT-hook gene 1 (HMGA1) is a non-histone nuclear binding protein that is developmentally regulated. HMGA1 is significantly overexpressed in and associated with high grade and advance stage of prostate cancer (PC). The oncogenic role of HMGA1 is at least mediated throug...
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