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Article

Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis.

Haematologica - 1 Mar 2011

Wilson Todd M, Maric Irina, Simakova Olga, Bai Yun, Chan Eunice Ching, Olivares Nicolas, Carter Melody, Maric Dragan, Robyn Jamie, Metcalfe Dean D

Abstract excerpt

Cooperating genetic events are likely to contribute to the phenotypic diversity of KIT-D816V systemic mastocytosis. In this study, 44 patients with KIT-D816V systemic mastocytosis were evaluated for coexisting NRAS, KRAS, HRAS or MRAS mutations. Activating NRAS mutations were identified in 2 of 8 patients with advanced disease. NRAS mutations were not found in patients with indolent systemic mastocytosis. To...

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Source

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Identifiers

PMID: 21134978
DOI: 10.3324/haematol.2010.031690
PMCID: PMC3046279

Genes

KIT
NRAS
HRAS
KRAS
MRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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