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Article

Role of the Rho pathway in regulating valvular interstitial cell phenotype and nodule formation.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2011

Gu Xiaoxiao, Masters Kristyn S

Abstract excerpt

The differentiation of valvular interstitial cells (VICs) to a myofibroblastic or osteoblast-like phenotype is commonly found in calcific valvular stenosis, although the molecular-level mechanisms of this process remain poorly understood. Due to the role of the Rho pathway in various vascular dis...

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Identifiers

PMID: 21131478
DOI: 10.1152/ajpheart.01178.2009
PMCID: PMC3044049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21131478-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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