Article
Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency.
Human molecular genetics - 15 Feb 2011
Castets Perrine, Bertrand Anne T, Beuvin Maud, Ferry Arnaud, Le Grand Fabien, Castets Marie, Chazot Guillaume, Rederstorff Mathieu, Krol Alain, Lescure Alain, Romero Norma B, Guicheney Pascale, Allamand Valérie
Abstract excerpt
Selenoprotein N (SelN) deficiency causes a group of inherited neuromuscular disorders termed SEPN1-related myopathies (SEPN1-RM). Although the function of SelN remains unknown, recent data demonstrated that it is dispensable for mouse embryogenesis and suggested its involvement in the regulation of ryanodine receptors and/or cellular redox homeostasis. Here, we investigate the role of SelN in satellite cell (SC)...
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