Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zebrafish and cellular models of SELENON-Congenital myopathy exhibit novel embryonic and metabolic phenotypes.

Skeletal muscle - 15 Mar 2025

Barraza-Flores Pamela, Moghadaszadeh Behzad, Lee Won, Isaac Biju, Sun Liang, Hickey Emily T, Rockowitz Shira, Sliz Piotr, Beggs Alan H

Abstract excerpt

BACKGROUND: SELENON-Congenital Myopathy (SELENON-CM) is a rare congenital myopathy caused by mutations of the SELENON gene characterized by axial muscle weakness and progressive respiratory insufficiency. Muscle histopathology may be non-specific, but commonly includes multiminicores or a dystrophic pattern. The SELENON gene encodes selenoprotein N (SelN), a selenocysteine-containing redox enzyme located in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Gene Knockout Techniques

Share to Muscle Proteins

Share to Myoblasts

Share to Myotonia Congenita

Share to Selenoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 40087793
DOI: 10.1186/s13395-025-00376-4
PMCID: PMC11909958

Genes

SELENON

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zebrafish and cellular models of SELENON-Congenital myopathy exhibit novel embryonic and metabolic phenotypes.PMID 40087793Read ↗

Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment.Semantic proximity Read ↗

Selenoprotein N and SEPN1-Related Myopathies: Mechanisms, Models, and Therapeutic Perspectives.Semantic proximity Read ↗

Selenoprotein N deficiency in mice is associated with abnormal lung development.Semantic proximity Read ↗

Generation and characterization of a novel gne Knockout Model in ZebrafishSemantic proximity Read ↗

Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.Semantic proximity Read ↗

Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency.Semantic proximity Read ↗

Selenoprotein function and muscle disease.Semantic proximity Read ↗

A novel zebrafish model of <i>SPEG</i> -related centronuclear myopathy (CNM): characterization and comparison with other CNM model zebrafishSemantic proximity Read ↗

Cored in the act: the use of models to understand core myopathies.Semantic proximity Read ↗

Core myopathies.Semantic proximity Read ↗

Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy.Semantic proximity Read ↗

Gne depletion during zebrafish development impairs skeletal muscle structure and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.