Hypermethylation of ATP ‐binding cassette B1 ( ABCB 1) multidrug resistance 1 ( MDR 1) is associated with cisplatin resistance in the A549 lung adenocarcinoma cell line

Abstract excerpt

Summary Development of multiple drug resistance has been attributed to the overexpression of theATP‐binding cassette B1 (ABCB1) gene. In this study, the major purpose was to assess the expression and methylation levels ofABCB1in human lung adenocarcinoma and to reveal the relationship between these processes and acquisition of cisplatin (DDP) resistance in the human cancer cell line A549. Methylation and...

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