Article
The S447X variant of lipoprotein lipase gene is inversely associated with severity of coronary artery disease.
Heart and vessels - 1 Jul 2011
Agirbasli Mehmet, Sumerkan Mutlu Cagan, Eren Fatih, Agirbasli Deniz
Abstract excerpt
Hyperlipidemia is a major risk factor for coronary artery disease (CAD). Lipoprotein lipase (LPL) is an important enzyme in lipoprotein metabolism. S447X polymorphism of the LPL gene has been implicated in the pathogenesis of CAD. Carriers of X447 allele were reported to have lower triglyceride and higher high-density lipoprotein cholesterol levels as well as a reduced risk of CAD. We hypothesized that S447X gene...
Topics
- Adult
- Biomarkers
- Case-Control Studies
- Chi-Square Distribution
- Coronary Angiography
- Coronary Stenosis
- Cross-Sectional Studies
- Gene Frequency
- Genetic Predisposition to Disease
- Heterozygote
- Homozygote
- Humans
- Lipids
- Lipoprotein Lipase