Article
Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41.
PLoS pathogens - 18 Nov 2010
Sabin Charles, Corti Davide, Buzon Victor, Seaman Mike S, Lutje Hulsik David, Hinz Andreas, Vanzetta Fabrizia, Agatic Gloria, Silacci Chiara, Mainetti Lara, Scarlatti Gabriella, Sallusto Federica, Weiss Robin, Lanzavecchia Antonio, Weissenhorn Winfried
Abstract excerpt
The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we present the crystal structure of the HK20 Fab in complex with a gp41 mimetic 5-Helix at 2.3 Å resolution. HK20 employs its heavy chain CDR H2 and H3 loops to bind into a conserved hydrophobic HR1...
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