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Article

Transient reduction of placental angiogenesis in PAI-1-deficient mice.

Physiological genomics - 24 Feb 2011

Labied Soraya, Blacher Silvia, Carmeliet Peter, Noël Agnès, Frankenne Francis, Foidart Jean-Michel, Munaut Carine

Abstract excerpt

Murine placentation is associated with the invasion of maternal endometrium by trophoblasts and an extensive maternal and fetal angiogenesis. Plasminogen activator inhibitor-1 (PAI-1) is transiently produced by spongiotrophoblasts and trophoblast giant cells at 10.5-11.5 days postcoitum (dpc). Knowing the key contribution of PAI-1 in the regulation of angiogenesis, we have now analyzed the consequence of PAI-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21119013
DOI: 10.1152/physiolgenomics.00147.2010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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