Article
The overlapping of local iron overload and HFE mutation in venous leg ulcer pathogenesis.
Free radical biology & medicine - 15 May 2006
Zamboni Paolo, Izzo Marcello, Tognazzo Silvia, Carandina Sergio, De Palma Massimiliano, Catozzi Linda, Caggiati Alberto, Scapoli Gianluigi, Gemmati D
Abstract excerpt
Chronic venous stasis determines red blood cell extravasation and either dermal hemosiderin deposits or iron-laden phagocytes. Several authors have suspected that iron could play a role in the pathogenesis of venous leg ulcers. They hypothesized that local iron overload could generate free radicals or activate a proteolytic hyperactivity on the part of metalloproteinases (MMPs) or else down-regulate tissue...
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