Article
A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability.
Journal of bacteriology - 1 Apr 1997
Onaka H, Sugiyama M, Horinouchi S
Abstract excerpt
A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) and its specific receptor protein (ArpA) are required for streptomycin production and aerial mycelium formation in Streptomyces griseus. A mutant strain HO1 that produced streptomycin and formed aerial mycelium and spores was derived...
Topics
- 4-Butyrolactone
- Animals
- Bacterial Proteins
- Cattle
- DNA Mutational Analysis
- DNA-Binding Proteins
- Growth Substances
- Ligands
- Molecular Weight
- Mutation
- Proline
- Repressor Proteins
- Spores, Bacterial
- Streptomyces
- Streptomycin