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Article

A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability.

Journal of bacteriology - 1 Apr 1997

Onaka H, Sugiyama M, Horinouchi S

Abstract excerpt

A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) and its specific receptor protein (ArpA) are required for streptomycin production and aerial mycelium formation in Streptomyces griseus. A mutant strain HO1 that produced streptomycin and formed aerial mycelium and spores was derived from an A-factor-deficient mutant, S. griseus HH1. The phenotypes of mutant HO1 were found to result from a single...

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Identifiers

PMID: 9098075
DOI: 10.1128/jb.179.8.2748-2752.1997
PMCID: PMC179026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability.PMID 9098075Read ↗

A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus.Semantic proximity Read ↗

The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation.Semantic proximity Read ↗

Cloning and functional analysis by gene disruption of a gene encoding a gamma-butyrolactone autoregulator receptor from Kitasatospora setae.Semantic proximity Read ↗

Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus.Semantic proximity Read ↗

Detection of an A-factor-responsive protein that binds to the upstream activation sequence of strR, a regulatory gene for streptomycin biosynthesis in Streptomyces griseusSemantic proximity Read ↗

Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.Semantic proximity Read ↗

Characterisation of a natural variant of the γ-butyrolactone signalling receptor.Semantic proximity Read ↗

Cloning of the conserved regulatory operon by its aerial mycelium-inducing activity in an amfR mutant of Streptomyces griseus.Semantic proximity Read ↗

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