Article
Mutant ataxin-3 promotes the autophagic degradation of parkin.
Autophagy - 1 Feb 2011
Durcan Thomas M, Fon Edward A
Abstract excerpt
There is growing evidence that autophagy plays a key role in neurodegenerative diseases. For instance, stimulating autophagy is neuroprotective both in vitro and in vivo in models of trinucleotide-repeat diseases such as Machado-Joseph disease (MJD). Similarly, proteins associated with familial forms of Parkinson disease (PD) such as parkin and PINK1 converge on the autophagy pathway. Yet, despite these shared...
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