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Article

Calpain digestion and HSP90-based chaperone protection modulate the level of plasma membrane F508del-CFTR.

Biochimica et biophysica acta - 1 Jan 2011

Averna Monica, Stifanese Roberto, Grosso Raffaella, Pedrazzi Marco, De Tullio Roberta, Salamino Franca, Sparatore Bianca, Pontremoli Sandro, Melloni Edon

Abstract excerpt

We are here showing that peripheral mononuclear blood cells (PBMC) from cystic fibrosis (CF) patients contain almost undetectable amounts of mature 170 kDa CF-transmembrane conductance regulator (CFTR) and a highly represented 100 kDa form. This CFTR protein, resembling the form produced by calpain digestion and present, although in lower amounts, also in normal PBMC, is localized in cytoplasmic internal...

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Source

Identifiers

PMID: 21111762
DOI: 10.1016/j.bbamcr.2010.11.008

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calpain digestion and HSP90-based chaperone protection modulate the level of plasma membrane F508del-CFTR.PMID 21111762Read ↗

CFTR degradation and aggregation.Semantic proximity Read ↗

CFTR and Ca2+ signaling in cystic fibrosisSemantic proximity Read ↗

CFTR and chaperones: processing and degradation.Semantic proximity Read ↗

Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP.Semantic proximity Read ↗

The Calpain, Caspase 12, Caspase 3 Cascade Leading to Apoptosis Is Altered in F508del-CFTR Expressing CellsSemantic proximity Read ↗

Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.Semantic proximity Read ↗

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.Semantic proximity Read ↗

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive.Semantic proximity Read ↗

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.Semantic proximity Read ↗

Multiple proteolytic systems, including the proteasome, contribute to CFTR processingSemantic proximity Read ↗

The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.Semantic proximity Read ↗

Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current.Semantic proximity Read ↗

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