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Article

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive.

Biochimica et biophysica acta - 1 May 2006

Hegedus Tamás, Aleksandrov Andrei, Cui Liying, Gentzsch Martina, Chang Xiu-Bao, Riordan John R

Abstract excerpt

Most cystic fibrosis (CF) patients carry the F508del mutation in the CFTR chloride channel protein resulting in its misassembly, retention in the endoplasmic reticulum (ER), and proteasomal degradation. Therefore, characterization of the retention and attempts to rescue the mutant CFTR are a majo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16624253
DOI: 10.1016/j.bbamem.2006.03.006

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16624253-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive.PMID 16624253Read ↗

Rescue of F508del CFTR: Commentary on "F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive".Semantic proximity Read ↗

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Protein Processing and Inflammatory Signaling in Cystic Fibrosis: Challenges and Therapeutic StrategiesSemantic proximity Read ↗

Interplay between ER exit code and domain conformation in CFTR misprocessing and rescue.Semantic proximity Read ↗

Therapeutic approaches to repair defects in deltaF508 CFTR folding and cellular targeting.Semantic proximity Read ↗

Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.Semantic proximity Read ↗

Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic ReticulumSemantic proximity Read ↗

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.Semantic proximity Read ↗

Rescue of functional DeltaF508-CFTR channels by co-expression with truncated CFTR constructs in COS-1 cells.Semantic proximity Read ↗

Regulated recycling of mutant CFTR is partially restored by pharmacological treatment.Semantic proximity Read ↗

Misassembled mutant DeltaF508 CFTR in the distal secretory pathway alters cellular lipid trafficking.Semantic proximity Read ↗

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