Article
Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP.
The EMBO journal - 15 Dec 1994
Lukacs G L, Mohamed A, Kartner N, Chang X B, Riordan J R, Grinstein S
Abstract excerpt
Metabolic labeling experiments followed by immunoprecipitation were performed to investigate the kinetics, location and inhibitor sensitivity of degradation of both wild-type (wt) and mutant (delta F508) cystic fibrosis conductance transmembrane regulator (CFTR). At the earliest stages of the bio...
Topics
- Adenosine Triphosphate
- Animals
- Biological Transport
- CHO Cells
- Cell Compartmentation
- Cricetinae
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Endopeptidases
- Endoplasmic Reticulum
- Glycoproteins
- Golgi Apparatus
- Humans
- Membrane Proteins
- Mutation