Article
Human monoclonal anti-D with reactivity against category DVI cells used in blood grouping and determination of the incidence of the category DVI phenotype in the DU population.
Vox sanguinis - 1 Jan 1990
Leader K A, Kumpel B M, Poole G D, Kirkwood J T, Merry A H, Bradley B A
Abstract excerpt
B-lymphoblastoid cell lines transformed by Epstein-Barr virus were produced from cells obtained from a hyperimmunised donor with serum anti-D activity against category DVI red cells and enriched for this activity by rosetting with category DVI red cells. Three clones produced IgG1 anti-D and had stable cell growth and continuous secretion of antibody in prolonged culture. The monoclonal antibodies reacted with...
Topics
- Antibodies, Monoclonal
- Blood Grouping and Crossmatching
- Cell Transformation, Viral
- Humans
- Phenotype
- Rh-Hr Blood-Group System