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Article

Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1.

The Journal of biological chemistry - 10 Jan 2003

Kong Geoffrey K-W, Polekhina Galina, McKinstry William J, Parker Michael W, Dragani Beatrice, Aceto Antonio, Paludi Domenico, Principe Daniela Rossi, Mannervik Bengt, Stenberg Gun

Abstract excerpt

In human glutathione transferase P1-1 (hGSTP1-1) position 146 is occupied by a glycine residue, which is located in a bend of a long loop that together with the alpha6-helix forms a substructure (GST motif II) maintained in all soluble GSTs. In the present study G146A and G146V mutants were gener...

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PMID: 12414796
DOI: 10.1074/jbc.M209581200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12414796-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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