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Article

Analysis and verification of the HMGB1 signaling pathway.

BMC bioinformatics - 15 Oct 2010

Gong Haijun, Zuliani Paolo, Komuravelli Anvesh, Faeder James R, Clarke Edmund M

Abstract excerpt

BACKGROUND: Recent studies have found that overexpression of the High-mobility group box-1 (HMGB1) protein, in conjunction with its receptors for advanced glycation end products (RAGEs) and toll-like receptors (TLRs), is associated with proliferation of various cancer types, including that of the breast and pancreatic. RESULTS: We have developed a rule-based model of crosstalk between the HMGB1 signaling pathway...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21106117
DOI: 10.1186/1471-2105-11-S7-S10
PMCID: PMC2957678

Genes

HMGB1
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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