Article

Modeling causal signal propagation in multi-omic factor space with COSMOS

2024-07-17

Abstract excerpt

Understanding complex diseases requires approaches that jointly analyze omics data across multiple biological layers, including signaling, gene regulation, and metabolism. Existing data-driven multi-omics analysis methods, such as multi-omics factor analysis (MOFA), can identify associations between molecular features and phenotypes, but they are not designed to integrate existing mechanistic molecular knowledge,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93c312b6-de3d-5f10-812f-bbd093562238
DOI: 10.1101/2024.07.15.603538

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling causal signal propagation in multi-omic factor space with COSMOSDOI 10.1101/2024.07.15.603538Read

Causal integration of multi-omics data with prior knowledge to generate mechanistic hypothesesSemantic proximity Read

SignalingProfiler 2.0 a network-based approach to bridge multi-omics data to phenotypic hallmarks.Semantic proximity Read

<i>SignalingProfiler</i> 2.0: a network-based approach to bridge multi-omics data to phenotypic hallmarksSemantic proximity Read

MPAC: a computational framework for inferring pathway activities from multi-omic dataSemantic proximity Read

Explainable multi-view framework for dissecting intercellular signaling from highly multiplexed spatial dataSemantic proximity Read

Combining prior knowledge and transcriptomics data for logic models of patient subgroupsSemantic proximity Read

Multi-Omics factor analysis - a framework for unsupervised integration of multi-omic data setsSemantic proximity Read

MOFA-FLEX: A Factor Model Framework for Integrating Omics Data with Prior KnowledgeSemantic proximity Read

PIMO: Pathway-based Interpretable Multi-Omics interactions for multi-omics integrationSemantic proximity Read

Integrative pathway enrichment analysis of multivariate omics dataSemantic proximity Read

TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics dataSemantic proximity Read

DANSE: a pipeline for dynamic modelling of time-series multi-omics dataSemantic proximity Read