Association of TLR-4 and TNF-alpha polymorphisms with clinical symptoms and cytokine levels in patients with allergic rhinitis.

doi:10.1007/s00405-010-1424-7

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Article

Association of TLR-4 and TNF-alpha polymorphisms with clinical symptoms and cytokine levels in patients with allergic rhinitis.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 1 Apr 2011

Krasznai Magdolna, Szaniszlo Kinga, Kraxner Helga, Vargha Eszter, Kovacs Margit, Borocz Zoltan, Kaszas Edit, Mezei Gyorgyi, Cserhati Endre, Cseh Karoly

Abstract excerpt

Our objective was to determine the frequency of TNF-alpha -238, -308 G/A promoter and TLR-4 299 D/G and 399 T/I polymorphisms in healthy population and in patients with seasonal allergic rhinitis, and to examine its influences on serum TNF-alpha, TNF receptor-1, Fas, Fas-ligand, IgE levels and on clinical symptoms. A pilot study was performed in 66 patients with seasonal allergic rhinitis to ragweed pollen and...

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PMID: 21103885
DOI: 10.1007/s00405-010-1424-7

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