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Article

Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation.

Thrombosis and haemostasis - 1 Feb 2011

Schaafhausen Anne, Rost Simone, Oldenburg Johannes, Müller Clemens R

Abstract excerpt

Since the discovery of vitamin K epoxide reductase complex subunit 1 (VKORC1), the key enzyme for the regeneration of vitamin KH₂, numerous studies have addressed the role of VKORC1 in the posttranslational modification of vitamin K-dependent proteins. VKORC1 is also the target protein of anticoagulant drugs of the coumarin type (e.g. warfarin). Genetic variants in VKORC1 have recently been shown to significantly...

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Source

Identifiers

PMID: 21103663
DOI: 10.1160/TH10-07-0483

Genes

VKORC1
SERP1
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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