Article
CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
The EMBO journal - 5 Jan 2011
Granata Alessandra, Koo Seong Joo, Haucke Volker, Schiavo Giampietro, Warner Thomas T
Abstract excerpt
DYT1 dystonia is caused by an autosomal dominant mutation that leads to a glutamic acid deletion in torsinA (TA), a member of the AAA+ ATPase superfamily. In this study, we identified a novel-binding partner of TA, the subunit 4 (CSN4) of CSN signalosome. TA binds CSN4 and the synaptic regulator snapin in neuroblastoma cells and in brain synaptosomes. CSN4 and TA are required for the stability of both snapin and...
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